MSG Studies

 (The following list was obtained from Jack and Adrienne Samuels of


Allen, D. H.,Delohery, J., & Baker, G. J. Monosodium L-glutamate-induced asthma. Journal of Allergy and Clinical Immunology. 80:No 4, 530-537, 1987.

Allen, D. H., and Baker, G. J. Chinese-restaurant asthma. N Engl JMed. 305: 1154-1155, 1981.

Anderson, S. A., and Raiten, D. J. Safety of amino acids used as dietary supplements. Prepared for the Food and Drug Administration under contract No FDA 223-88-2124 by the Life Sciences Research Office, FASEB. July, 1992. Available from: Special Publications, FASEB, Rockville, MD.

Asnes, R. S. Chinese restaurant syndrome in an infant. Clin Pediat. 19: 705706, 1980. Beal, M. F. Mechanisms of excitotoxicity in neurologic diseases. FASEB j. 6: 3338-3344; 1992.

Blaylock, R. L. Excitotoxins: The Taste that Kills Santa Fe, Health Press, 1994. Broadwell, R. D., and Sofroniew, M. V. Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Exp Neurol. 120: 245-263, 1993.

Choi, D. W., and Rothman. S. M. The role of glutamate neurotoxicityin hypoxic-ischemic neuronal death. Annu Rev Neurosci. 13: 171-182, 1990.

Choi, D. W. Amyotrophic lateral sclerosis and glutamate-too much of a good thing? Letter. N Engl J Med. 326: 1493-1495, 1992.

Cochran, ]. W., and Cochran A. H. Monosodium glutamania: the Chinese Restaurant Syndrome revisited. JAMA. 252: 899, 1984.

Colman, A. D. Possible psychiatric reactions to monosodium glutamate. N EnglJ Med. 299: 902, 1999.

During, M. J., and Spencer, D. D. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 341: 16071610, 1993.

Elman, R. The intravenous use of protein and protein hydrolysates. Ann New York Acad Sc. 47: 345-357, 1946.

Fisher, K. N.,Turner, R. A., Pineault, G., Kleim, J., and Saari,M. J. The post weaning housing environment determines expression of learning deficit associated with neonatal monosodium glutamate(M. S. G. ). Neurotoxicology and Teratology. 13(5):507-13, 1991.

Freed, D. L. J. and Carter, R. Neuropathy due to monosodium glutamate intolerance. Annals of Allergy. 48: 96-97, 1982. Frieder, B. and Grimm, V. E. Prenatal monosodium glutamate (MSC)treatment given through the mother's diet causes behavioral deficits in rat offspring. Intern J Neurosci. 23: 117-126, 1984.

Frieder, B. and Grimm, V. E. Prenatal monosodium glutamate. Neurochem. 48: 1359-1365, 1987. Cann, D. Ventricular tachycardia in a patient with the; Chinese restaurant syndrome; Southern Medical J. 70: 879-880,1977.

Gao, J., Wu, J., Zhao, X. N., Zhang, W. N., Zhang, Y. Y., and Zhang,Z. X. [Transplacental neurotoxic effects of monosodium glutamateon structures and functions of specific brain areas of filialmice. ] Sheng Li Hsueh Pao Acta Physiologica Sinica. 46(1):44-51,1994.

Gordon, W. P. Neurotoxic theory of infantile autism. In: Neurobiology of infantile autism. Proceedings of the International Symposium on Neurobiology of Infantile Autism, Tokyo, 10-11 November 1990.

Eds H. Naruse and E. M. Ornitz. Amsterdam: Excerpta Medica, 1992. Gore, M. E., and Salmon, P. R. Chinese restaurant syndrome: fact orfiction. Lancet. 1(8162):251, 1980.

Kenney, R. A. The Chinese restaurant syndrome: an anecdote revisited. Fd ChemToxic. 24: 351-354, 1986.

Kenney, R. A. and Tidball, C. S. Human susceptibility to oral monosodium L-glutamate. Am J Clin Nutr. 25: 140-146, 1972.

Kubo, T, Kohira, R., Okano, T., and Ishikawa, K. Neonatal glutamate can destroy the hippocampal CAl structure and impair discrimination learning in rats. Brain Research. 61(1: 311-314,1993.

L.evey, S., Harroun, J. E. and Smyth, C. I. Serum Glutamic acid levels and the occurrence of nausea and vomiting after intravenous administration of amino acid mixtures. J Lab ClinMed. 34: 1238-1248, 1949.

I,ipton, S. A., and Rosenberg, PA. Excitatory amino acids as a final common pathway for neuroiogic disorders. N Engl J Med. 330: 613-622, 1994.

Lynch, J. E Jr., .ewis, L. M., Hove, E. L., and Adkins, J. S. Division of Nutrition, FDA, Washington, D. C. 20204. Effect ofmonosodium L-glutamate on development and reproduction in rats. Fed Proc. 29: 567Abs, 1970.

Lynch, J. E,Jr., Lewis, L. M., and Adkins, J. S. (Division of Nutrition, FDA, Washington, D. C. 20204). Monosodium glutamate-induced hypcrglycemia in weanling rats. J S Fed Proc. 31: 1477,1971.

Martinet E, Castillo, J. Rodriguez, J. R., I,eira, R.,and Noya,M. Neuroexcitatory amino acid levels in plasma and cerebro spinal fluid during migraine attacks. Cephalalgia 13(2):89-93, 1993.

Neumann, H.H. Soup? It may be hazardous to your health. Am HeartJ. 92: 266, 1976.

Oliver. A. J., Rich, A. M., Reade, P. C.,Varigos, G. A., and Radden, B.G. Monosodium glutamate-related orofacial granulomatosis. Review and case report. Oral Surg Oral Med Oral Pathol. 71: 560-564, 1991.

Olney, J. W. Excitotoxin mediated neuron death in youth and oldage. In: Progress in Brain Research, Vol 86, ed P. Coleman, G. Higgins, and C. Phelps, pp 37-51. New York: Elsevier, 1990.

Olney, J. W. Excitotoxic amino acids and neuropsychiatric disorders. Annu Rev Pharmacol Toxicol. 30: 47-71, 1990.

Olney, J. W. Excitatory amino acids and neuropsychiatric disorders. Biol Psychiatry 26:505-525,1989.

Olney, J. W., Ho, O. L., and Rhee, V. Brain-damaging potential of protein hydrolysates. N Eng] J Med. 289: 391-393, 1973.

Olney, J. W., Labruyere, I., and DeGubareff, T. Brain damage in mice from voluntary ingestion of glutamate and aspartate. Neurobehav Toxicol. 2: 125-129, 1980.

Olney, J. W., Ho, O. L. Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature. (Lend) 227:609-611, 1970.

Olney, J. W. Glutamate-induced retinal degeneration in neonatal mice. Electron-microscopy of the acutely evolving lesion. J Neuropathol Exp Neurol. 28: 455-474, 1969.

Olney, J. W. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science. 164: 719-721,1969.

Pohl, R., Balon, R., and Berchou, R. Reaction to chicken nuggets in a patient taking an MAOI.,4m J Psychiatry. 145: 651, 1988.

Pradhan, S. N., Lynch, J. F., Jr. Behavioral changes in adult rats treated with monosodium glutamate in the neonatal state. Arch Int Pharmacodyn Ther. 197: 301-304, 1972.

Price, M. T., Olney, J. W., Lowry, O. H. and Buchsbaum, S. Uptake of exogenous glutamate and aspartate by circumventricular organs but not other regions of brain. ] Ncurochem. 36:2774-1990, 1981.

Raiten, D. J., Talbot, J. M., Fisher, K. D. Analysis of Adverse Reactions to Monosodium Glutamate (MSG), Bethesda, Md:American Institute of Nutrition; 1996.

Ratner, D., Esmel, E.,and Shoshani, E. Adverse effects of monosodium glutamate: a diagnostic problem. Israel J Med Sci. 20:252-253, 1984.

Reif-Lehrer, L. A questionnaire study of the prevalence of Chinese Restaurant Syndrome. Fed Proc. 3.1617-1623, 1977.

Reif-Lehrer, L. Possible significance of adverse reactions to glutamate in humans. Federation Proceedings. 35: 2205-2221, 1976.

Reif-Lehrer, L. and Stemmermann, M. B. Correspondence: Monosodium glutamate intolerance in children. N Engl J Med. 293: 1204-1205,1975.

Rothstein, J, D., Martin, L. J., and Kuncl, R. W. Decreased glutamate transport by the brain and spinal cord in amyotrophiclateral sclerosis. N Engl J Med. 326: 1464-14(18, 1992.

Said, S. I., Berisha, H.,and Pakbaz, H. NMDA receptors in the lung: activation triggers acute injury that is prevented by NO synthase inhibitor and by VIP. Society for Neuroscience Abstracts20:1994.

Samuels, A., Ph.D. Excitatory amino acids in neurologic disorders: letter to the editor. N Engl J Med. 331: 274-275, 1994.

Samuels, A. Ph.D. Monosodium L-glutamate: a double-blind study and review. Letter to the editor. Food and Chemical Toxicology. 31: 1019-1035,

Sathave, N. and Bodnar, R. J. Dissociation of opioid and nonopioid analgesic responses following adult monosodium glutamate pretreatment. Physiology and Behavior. 46: 217-222, 1989.

Sauber, W. J. What is Chinese restaurant syndrome? Lancet. 1(8170): 721-722, 1980.

Schainker, B., and Olney, J. W. Glutamate-type hypothalamic-pituitary syndrome in mice treated with aspartate or cysteate in infancy. J Neural Transmission. 35: 207-215, 1974.

Schaumburg, H. H.,Byck, R.,Gerstl, R.,and Mashman, J.H. Monosodium L-glutamate: its pharmacology and role in the Chinese Restaurant Syndrome. Science. 163: 826-828, 1969.

Scher, W., and Scher, B. M. A possible role for nitric oxide in glutamate (MSC)-induced Chinese restaurant syndrome, glutamate-induced asthma, 'Hot-dog headache', pugilistic Alzheimer's disease, and other disorders. Medicalhypothcses.38:185-188,1992.

Schinko, I. In: Cerebrospinal flussigkeit-csf, ed D. Dommasch and H. G. Mertens, pp 66-99. Stuttgart: Thieme, 1980.

Schwartz, G. R. In Bad Taste: The MSC Syndrome. Santa Fe: HealthPress, 1988.

Scopp, A. L. MSC and hydrolyzed vegetable protein induced headache: review and case studies. Headache. 31:107-110, 1991.

Spencer, P. S. Guam ALS/ Parkinsonism-dementia: a long-laten cyneurotoxic disorder caused by slow toxin(s) in food? Can JNeurol Sci. 14:347-357, 1987.

Spencer, P.S. Environmental excitotoxins and human neurodegeneration. Conference on excitotoxic amino acids, London,November, 1991. (Peter S. Spencer, Center for research on occupational and environmental toxicology, Oregon Health Sciences University, Portland, Oregon 97201 USA)

Spencer, P. S. Western pacific ALS-Parkinsonism-dementia: A model of neuronal aging triggered by environmental toxins. In Parkinsonism and Aging, ed U. B. Calne, et al., pp 133-144. NewYork: Raven Press, 1989.

Spencer, P. S., Ross, S. M., Kisby, G., and Roy, D. N. Western Pacific ALS: putative role of cycad toxins. In: AmyotrophicLateral Sclerosis: Current Clinical and Pathophysiological Evidence for Differences in Etiology, ed J. A. Hudson. Toronto: University of Toronto Press, 1990.

Spencer, P. S. Linking cycad to the etiology of western pacifica myotrophic lateral sclerosis. In: ALS. New Advances in Toxicology and Epidemiology, ed E C. Rose and F. H. Norris. Smith-Gordon, 1990.

Spencer, P S. Amyotrophic lateral sclerosis and other motor neuron diseases. In: Advances in Neurology, Vol 56, ed L. P. Rowland. New York: Raven Press, 1991. Squire, E. N. Jr. Angio-oedema and monosodium glutamate. Lancet. 988, 1987.


Battling the MSG Myth